Biology and Health Technologies

Keywords: 3D-Print

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The 3D printing plate proposes the realization of objects by 3D printing

Keywords: Artificial masticator, mastication, Food oral processing

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The platform “Articficial masticator” of University Clermont Auvergne has been devised to simulate Food Oral processing in vitro, in either healthy or deficient conditions for mastication while allowing a permanent control of the process. It offers the collection of the whole bolus at any time of the process, and its rheological, granulometrical and/or biochemical characterization.

Keywords: X-ray irradiation, eukaryotic cell cultures, production of mutant animal or plant lines, dosimetry

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The Pavirma platform is equipped with a self-protected X ray irradiator (PXI320) of 320 KV, 8Gy/min, with a large irradiation chamber for processing large samples (biological or other), and associated biological equipments including a laminar flow hood, a CO₂ incubator for the cultivation of eukaryotic cells, a centrifuge and microscopes.

Keywords: Microscopy, Electron Microscopy, Photonic, Cytometry, service delivery

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Microscopy is an indispensable technique serving materials science and life. All microscopes (photonics, electron, etc.) are complementary with different resolutions to answer scientific questions of researchers and industrials.

Keywords: lipid, chromatography, fatty acids, plasma lipids

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The facility could analyze the fatty acid profile of biological or food matrices by gas chromatography (GC-FID), study of phospholipid classes by HPLC and blood lipids by spectrophotometry.

Keywords: Integrated exploration of immune response polarization (original models of cellular polarization) / Cell cultures 2 and 3D (organoids) / Experimental model of overweight/obesity and/or cancer and/or physical activity / Biological Screening and phytochemistry

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Our research team is specialized in the phenotypic and functional characterization of IMMUNOCOMPETENT CELLS (ICCs) in physio/pathological states particularly in relation to INFLAMMATION and associated chronic diseases such as overweight, obesity and cancer.
In addition, our team has in PHYTOCHEMY in order not only to extract and purify but also to characterize active ingredients of natural origin.

Keywords: Fluorescence / Laser scanning confocal microscopes/ Spinning Disk / Biology / live cell imaging

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The CLIC facility (Clermont Imagerie Confocale) provides support in photonic microscopy by supplying the users with several optical systems, mainly confocal microscopes. The facility is available for local public research community and private companies.
Our set-ups allow a broad array of applications : large spectrum of fluorescent dyes, fixed or living cells or tissues, need of a high sensibility or a high resolution or a high acquisition speed.

Keywords: Cancer, promotion, investigation, authorization for a research site, ISO9001 certification

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Clinical Research Division (CRD) at Jean PERRIN Comprehensive Cancer Center is directed by Pr Xavier DURANDO. This unit brings together the expertise necessary for the implementation of any high-level research in oncology involving the patient, clinical research (Phases I, II, III, IV, database management) and translational research.

Keywords:microorganism, culture, anaerobic, biofilm, DNA, RNA, protein quantification

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The devices forming this platform make it possible to cultivate and characterize microorganisms on a large scale, including under strict anaerobic conditions and biofilms and to analyze at the individual level the genome of heterogeneous populations.

Keywords: Flow cytometry, transmission electron microscopy, enumeration, isolation

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The goal of the Cytometry and Electron Microscopy platform is to give scientists access to an efficient instrumental park dedicated to the structural and functional analysis of biological entities from counting, isolation, cytometry purification approaches to ultra-fine structural analysis by electron microscopy.

Keywords: Digestive environment, in vitro model, Nutrition, Health

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The Digestive Environment Simulation Platform proposes to study in vitro the behaviour and/or effects on the digestive environment of any incoming ingredient, microorganism, pre-treatment, formulation, etc., during the digestive process or colic fermentation of Man or the monogastric animal.

Keywords: spermatozoa, nuclear integrity, cryoconservation, germ cell toxicity, immune contraceptive strategies

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Service and R&D platform for the evaluation and/or improvement of sperm parameters with or without cryopreservation in mammals (human, livestock, research laboratory animal models, species preservation programs,..). Evaluation of gametotoxic effects on proprietary sperm-sensitize mouse lines. Development of immunocontraceptive programs on rodents harmful to the environment.

Keywords: Drosophila, transgenesis, genome modifications, CRISPR/Cas9, disease models

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• Generation of transgenic lines using P-element transformation and site-specific transgenesis
• CRISPR/CAS9 genome engineering in Drosophila

Keywords: Drug delivery development / physicochemical characterization / biopharmaceutical characterization

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The Galbiopharm platform (Galenic and biopharmaceutic characterization) provides the scientific community with a range of state-of-the-art technologies to i) develop conventional or multiparticulate drug delivery systems and ii) characterize in vitro (dissolution, permeability), ex vivo (absorption) and in vivo (pharmacokinetic) physicochemical and biopharmaceutic properties.

Keywords: Gene capture by hybridization, Metagenomics, Sequencing, Bioinformatics

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Gene capture by hybridization provides access to known or unknown genetic informations for all types of organisms.

Keywords: genotyping, long fragment sequencing, optical mapping, DNA extraction, high throughput, DNA chip

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The Gentyane platform provides R & D and service for the scientific community and socio-economic partners of a wide range of high-throughput chip genotyping, high-throughput fragmentation sequencing and optical map applications.

Keywords: PET, SPECT, CT, US, MRI, Imaging, in vivo, multimodality

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IVIA platform offers to the academic and industrial scientific community the cutting-edge equipment’s for in vivo imaging. The large spectrum of imaging strategies offers by IVIA platform allows to collect structural and functional information of the small animal to the human.
 

Keywords: Performance, evaluation, physical activity, physical fitness, body composition

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The AME2P laboratory is equipped from a platform for assessing physical fitness in healthy, sports or diseased people.

Keywords: Metabolism, Environment, mass specrometer, NMR spectrometer, statistic studies

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Platform of "Exploration of Metabolism" (PFEM) is a technological and scientific platform that supports metabolomic and proteomic projects. This INRA-UCA joint infrastructure obtained the French IBiSA labelisation in 2013 and NF X50-900 certification in 2015. PFEM is member of the French National Facility in metabolomics and proteomics (PIA) MetaboHUB (MTH ; www.metabohub.fr) wich aims to develop tools, methodologies and support major projects involving metabolomic and fluxomic approaches.

Keywords: laser microdissection, biological tissue, spatial analysis, histology

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Laser microdissection allows, from frozen or paraffin-embedded sections, the isolation of large tissue areas or single cells under morphological control for RNA, DNA, protein studies, etc.